Kaolin (Last Updated - 2/27/2005)
-aka. aluminum silicate
-along with prekallikrein & high molecular weight kininogen (HMWK) catalyzes the activation of Factor XII to XIIa to initiate the intrinsic pathway
-this step produces not only Factor XIIa but also kallikrein
-click here to view an image of the clotting cascade
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References:
Goodman & Gilman's: The Pharmacologic Basis Of Therapeutics - 10th Edition - 2001. Chapter 55.